tailieunhanh - báo cáo khoa học: "HLA-matched sibling transplantation with G-CSF mobilized PBSCs and BM decreases GVHD in adult patients with severe aplastic anemia"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:HLA-matched sibling transplantation with G-CSF mobilized PBSCs and BM decreases GVHD in adult patients with severe aplastic anemia | Zi-Min et al. Journal of Hematology Oncology 2010 3 51 http content 3 1 51 JOURNAL OF HEMATOLOGY ONCOLOGY LETTER TO THE EDITOR Open Access HLA-matched sibling transplantation with G-CSF mobilized PBSCs and BM decreases GVHD in adult patients with severe aplastic anemia Sun Zi-Min Liu Hui-Lan Geng Liang-Quan Wang Xin-Bing Yao Wen Liu Xin Ding Kai-Yang Han Yong-Sheng Yang Hui-Zhi Tang Bo-lin Tong Juan Zhu Wei-Bo Wang Zu-Yi Abstract Background Allogeneic hematopoietic stem cell transplantation allo-HSCT is an effective treatment for severe aplastic anemia SAA . However graft failure and graft-versus-host disease GVHD are major causes of the early morbidity in Allo-HSCT. Methods To reduce graft failure and GVHD we treated fifteen patients with SAA using high- dose of HSCT with both G-CSF mobilized PB and BMSCs from HLA-identical siblings to treat patients with SAA. Results All patients had successful bone marrow engraftment. Only one patient had late rejection. Median time to ANC greater than X 109 L and platelet counts greater than 20 X 109 L was 12 and days respectively. No acute GVHD was observed. The incidence of chronic GVHD was . The total three-year probability of disease-free survival was . Conclusion HSCT with both G-CSF mobilized PB and BMSCs is a promising approach for heavily transfused and or allo-immunized patients with SAA. To the Editor Allogeneic hematopoietic stem cell transplantation allo-HSCT is a cure for patients with severe aplastic anemia SAA . However complications such as graft failure and graft-versus-host disease GVHD have limited the application of allo-HSCT 1 2 . Increasing the number of donor blood stem cells decreases graft failure however high-dose of blood stem cell transplantation also increases the incidence of GVHD 3 . A combination of un-manipulated marrow and T-cell depleted PBSC as the stem cell source for SAA have shown rapid engraftment without increasing the risk of GVHD 4 5 . Here we .