tailieunhanh - báo cáo khoa học: "Autoimmune conditions and hairy cell leukemia: an exploratory case-control study"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Autoimmune conditions and hairy cell leukemia: an exploratory case-control study | Anderson and Engels Journal of Hematology Oncology 2010 3 35 http content 3 1 35 JOURNAL OF HEMATOLOGY ONCOLOGY RESEARCH Open Access Autoimmune conditions and hairy cell leukemia an exploratory case-control study Lesley A Anderson1 Eric A Engels2 Abstract Background Case reports suggest that hairy cell leukemia HCL may be associated with autoimmune conditions however no systematic investigations in this area have been undertaken. Methods Using the United States Surveillance Epidemiology and End Results Medicare linked database we conducted an exploratory study comparing autoimmune conditions in 418 HCL cases aged 65 years and 160 086 controls. Results Overall the proportion with autoimmune conditions was similar between HCL cases and controls n 79 and n 29 284 respectively . Before diagnosis selection there was no overall difference in the prevalence of autoimmune conditions in HCL cases n 37 compared with controls n 14 085 p . However compared with controls HCL cases more frequently had sarcoidosis OR 95 CI Sjogren syndrome OR 95 CI and erythema nodosum OR 37 95 CI before diagnosis. Autoimmune conditions were also more common in HCL cases than controls around the time of diagnosis selection p but not subsequently. Conclusions The findings do not support an overall relationship between autoimmune conditions and HCL although the association with some autoimmune conditions prior to HCL diagnosis may warrant further investigation. Our findings also suggest that autoimmune conditions in HCL patients may be detected around the time of diagnosis. Introduction Hairy cell leukemia HCL is a rare indolent B-cell neoplasm accounting for approximately 2 of all nonHodgkin lymphomas NHLs in the . 1 . Organic solvents and some medical conditions including anemia could be related to development of HCL 2 . Factors affecting the immune system including autoimmune conditions are associated with an .

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