tailieunhanh - báo cáo khoa học: "Role of Wnt canonical pathway in hematological malignancies"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Role of Wnt canonical pathway in hematological malignancies | GE and Wang Journal of Hematology Oncology 2010 3 33 http content 3 1 33 JOURNAL OF HEMATOLOGY ONCOLOGY REVIEW Open Access Role of Wnt canonical pathway in hematological malignancies Xueling GE Xin Wang Abstract Wnt canonical signaling pathway plays a diverse role in embryonic development and maintenance of organs and tissues in adults. It has been observed that Wnt p-catenin signaling pathway is involved in the pathogenesis of many carcinomas. Moreover Wnt p-catenin pathway has been revealed to be associated with angiogenesis. Wnt canonical pathway signaling has great potential as a therapeutic target. It has been disclosed that some hematological malignancies such as chronic lymphocytic leukemia mantle cell lymphoma may occur partly due to the constitutive activation of Wnt canonical signaling pathway. This review will summarize the latest development in Wnt canonical signaling pathway and its roles in tumorigenesis and angiogenesis. Introduction Wnt canonical signaling pathway acts a significant part in embryonic development and in maintenance of organs and tissues in adults. In the past two decades medical scientists have devoted themselves to understanding the cellular and molecular mechanisms of Wnt signaling. A lot of studies indicate that Wnt canonical pathway involves in the pathogenesis of a range of disease including many kinds of carcinomas. Hematological malignancies are the types of carcinoma that affect blood bone marrow and lymph nodes. They may derive from either of the two major blood cell lineages myeloid and lymphoid cell lines. The incidence of hematological malignancies has been increasing steadily in the world for the past years but their etiology and pathogenesis has not been well understood involving areas of chromosome aberrations apoptosis inhibition abnormal activation of signaling pathways angiogenesis et al. In this review we focus on the role of Wnt canonical signaling in carcinomas especially in hematological .