tailieunhanh - báo cáo khoa học: "Pancytopenia associated with clonazepam"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Pancytopenia associated with clonazepam | Bautista-Quach et al. Journal of Hematology Oncology 2010 3 24 http content 3 1 24 JOURNAL OF HEMATOLOGY ONCOLOGY CASE REPORT Open Access Pancytopenia associated with clonazepam Marnelli A Bautista-Quach1 Yu-Min Liao2 Chung-Tsen Hsueh3 Abstract We report a case of a 48-year-old Chinese female with end-stage renal disease and chronic anemia on hemodialysis. Clonazepam was prescribed for myoclonus disorder two weeks prior to her hospitalization. Subsequently she was hospitalized for neutropenic fever with thrombocytopenia and worsening anemia. Bone marrow examination demonstrated a markedly hypocellular marrow 10-20 total cellularity . Clonazepam was discontinued with gradual improvement of thrombocytopenia and neutropenia in 1-2 weeks. To our knowledge this is the first reported case of pancytopenia associated with clonazepam. We recommend patients taking clonazepam to be monitored with regular complete blood count to check for clinically significant pancytopenia or thrombocytopenia. Introduction Clonazepam a benzodiazepine derivative is used for the treatment of epilepsy psychiatric and neurologic disorders 1 . Clonazepam has also been utilized in alleviating movement disorders and restless leg syndrome in patients with end-stage renal disease 2 3 . Cases of thrombocytopenia from clonazepam and other benzodiazepines have been described 4-6 . We report an event of pancytopenia associated with clonazepam in a patient with end-stage renal disease. Case Report A 48-year-old Chinese female with end-stage renal disease on hemodialysis and mild chronic anemia presented with fever chills and new-onset leukopenia and thrombocytopenia. She was started on clonazepam mg orally twice a day for myoclonus approximately two weeks prior. Her other medicines included erythropoietin felodipine aluminum hydroxide calcium carbonate labetalol folic acid and daily vitamin B complex. She received two units of packed red blood cells for worsening anemia with a .

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