tailieunhanh - báo cáo khoa học: "Management of stage one and two-E gastric large B-cell lymphoma: chemotherapy alone or surgery followed by chemotherapy?"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Management of stage one and two-E gastric large B-cell lymphoma: chemotherapy alone or surgery followed by chemotherapy? | Sbitti et al. Journal of Hematology Oncology 2010 3 23 http content 3 1 23 JOURNAL OF HEMATOLOGY ONCOLOGY SHORT REPORT Open Access Ma nagement of stage one and two-E gastric large B-cell lymphoma chemotherapy alone or surgery followed by chemotherapy Yassir Sbitti 1 2 Nabil Ismaili 2 Youssef Bensouda2 Habiba Kadiri3 Mohammed Ichou1 and Hassan Errihani2 Abstract Management of localized primary gastric B lymphoma PGL remains controversial. The aim of this study is to compare two treatments chemotherapy alone and surgery plus chemotherapy. Materials Records of all patients with a diagnosis of gastric lymphoma and which were treated in the National Institute of Oncology between 1999 and 2006 were reviewed and patients fulfilling the following criteria were included in this study histologically proven large-cell B lymphoma of the stomach complete clinical information stage I II disease according to the Musshoff staging patients who received surgery followed by chemotherapy group I or chemotherapy alone group II . Results This study included 82 patients who were treated for cancer in our Institute. All clinical and pathological features were similar between the two groups except that patients of group-I had significantly more stage II disease P than that of group II. Among the 52 patients who could be evaluated for response to chemotherapy there were 45 who had complete response to treatment 3 had partial response to the treatment and 4 had progressive disease. The projected 5-year relapse-free survival RFS and overall survival OS of group I were 95 CI and 95 CI - respectively. And the projected 5-year relapse-free survival RFS and OS of group II were 95 CI - and 95 CI - respectively. There were no statistically significant differences in RFS P and OS P between the two groups. Conclusion Our data suggest that chemotherapy alone may be a reasonable alternative treatment for