tailieunhanh - báo cáo khoa học: "Update in the management of chronic lymphocytic leukemi"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Update in the management of chronic lymphocytic leukemi | Journal of Hematology Oncology BioMed Central Open Access Review Update in the management of chronic lymphocytic leukemia Kami J Maddocksf and Thomas S Lin t Address The Ohio State University Division of Hematology-Oncology 320 West 10th Avenue Columbus Ohio 43210 USA Email Kami J Maddocks - Thomas S Lin - Corresponding author fEqual contributors Published 20 July 2009 Received 7 May 2009 Journal of Hematology Oncology 2009 2 29 doi 1756-8722-2-29 Accepted 20 July 2009 This article is available from http content 2 1 29 2009 Maddocks and Lin licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Advances in the treatment of chronic lymphocytic leukemia CLL have improved initial overall response OR rates complete response CR rates and progression free survival PFS . Despite these advances CLL remains incurable with standard therapies. Thus there remains a need for more effective therapies in both the upfront and relapsed setting particularly for patients with high-risk cytogenetic abnormalities such as del 11q22 and del 17p13 . The 2008 American Society of Hematology ASH Annual Meeting featured several presentations which highlighted the ongoing clinical advances in CLL. The benefit of adding rituximab to purine analog therapy in the upfront setting was demonstrated by a large randomized study which showed that the addition of rituximab to fludarabine and cyclophosphamide FCR significantly improved OR CR and PFS. The improvement in PFS directly resulted from an improved ability to eliminate minimal residual disease MRD in the peripheral blood highlighting the importance of MRD eradication. However a multicenter study suggested that the high CR .