tailieunhanh - báo cáo khoa học: "Adult B lymphoblastic leukaemia/lymphoma with hypodiploidy (-9) and a novel chromosomal translocation t(7;12)(q22;p13) presenting with severe eosinophilia – case report and review of literature"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Adult B lymphoblastic leukaemia/lymphoma with hypodiploidy (-9) and a novel chromosomal translocation t(7;12)(q22;p13) presenting with severe eosinophilia – case report and review of literature | BioMed Central Journal of Hematology Oncology Open Access Case report Adult B lymphoblastic leukaemia lymphoma with hypodiploidy -9 and a novel chromosomal translocation t 7 12 q22 p13 presenting with severe eosinophilia - case report and review of literature Farhat Abbas Bhatti Iftikhar Hussain and Muhammad Zafar Ali Address Department of Haematology PNS Shifa Hospital Karachi Pakistan Email Farhat Abbas Bhatti - farhatab@ Iftikhar Hussain - ammad_a1@ Muhammad Zafar Ali - tayyibasaad@ Corresponding author Published 21 June 2009 Received 22 April 2009 Journal of Hematology Oncology 2009 2 26 doi 1756-8722-2-26 Accepted 21 June 2009 This article is available from http content 2 1 26 2009 Bhatti et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Patients suffering from adult acute lymphoblastic leukemia are acutely ill and present most commonly with fever pallor bleeding lymphadenopathy hepatosplenomegaly and presence of lymphoblasts in the peripheral blood and bone marrow. We describe a rare presentation of acute lymphoblastic leukemia in a young adult male who had vague and minimal symptoms with mild splenomegaly. There was severe eosinophilia along with absence of blasts in the peripheral blood and 40 blasts with increase in eosinophils in the bone marrow. The blasts were positive for common precursor B cell markers on flow cytometry. The patient had a unique cytogenetic abnormality t 7 12 q22 p13 -9 not previously described in acute lymphoblastic leukemia. He was categorized as poor risk due to failure to achieve complete remission after induction with UK ALL XII .