tailieunhanh - báo cáo khoa học: "Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics | Journal of Hematology Oncology BioMed Central Open Access Review Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics Tara K Gregory1 David Wald2 Yichu Chen1 Johanna M Vermaat2 Yin Xiong1 and William Tse 1 Address Division of Medical Oncology University of Colorado Cancer Center University of Colorado School of Medicine Aurora Colorado USA and 2Department of Medicine Case Western Reserve University Cleveland Ohio USA Email Tara K Gregory - David Wald - Yichu Chen - Johanna M Vermaat - Yin Xiong - William Tse - Corresponding author Published 2 June 2009 Received 31 March 2009 Journal of Hematology Oncology 2009 2 23 doi 1756-8722-2-23 Accepted 2 June 2009 This article is available from http content 2 1 23 2009 Gregory et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Acute myeloid leukemia AML is a heterogenous disorder that results from a block in the differentiation of hematopoietic progenitor cells along with uncontrolled proliferation. In approximately 60 of cases specific recurrent chromosomal aberrations can be identified by modern cytogenetic techniques. This cytogenetic information is the single most important tool to classify patients at their initial diagnosis into three prognostic categories favorable intermediate and poor risk. Currently favorable risk AML patients are usually treated with contemporary chemotherapy while poor risk AML patients receive allogeneic stem cell transplantation if suitable stem cell donors exist. The largest subgroup of AML patients 40 have no identifiable cytogenetic

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