tailieunhanh - báo cáo khoa học: "R-CHOP versus R-CVP in the treatment of follicular lymphoma: a meta-analysis and critical appraisal of current literature"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: R-CHOP versus R-CVP in the treatment of follicular lymphoma: a meta-analysis and critical appraisal of current literature | Journal of Hematology Oncology BioMed Central Research R-CHOP versus R-CVP in the treatment of follicular lymphoma a meta-analysis and critical appraisal of current literature Ganguly Siddhartha and Patel Vijay Open Access Address Division of Hematology Oncology Department of Medicine University of Kansas Medical Center Kansas City Kansas USA Email Ganguly Siddhartha - sganguly@ Patel Vijay - vpatel2@ Corresponding author Published 24 March 2009 Received 9 January 2009 Journal of Hematology Oncology 2009 2 14 doi 1756-8722-2-14 Accepted 24 March 2009 This article is available from http content 2 1 14 2009 Siddhartha and Vijay licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Purpose R-CHOP rituximab with cyclophosphamide doxorubicin vincristine and prednisone and R-CVP rituximab with cyclophosphamide vincristine and prednisone have both been used successfully in the treatment of patients with symptomatic follicular lymphoma FL . No study has compared the efficacy of the two treatment modalities and attempted to evaluate the role of anthracyclines in the management of patients with FL. We conducted a meta-analysis of relevant literature comparing the two treatment arms for FL with response being the final endpoint. Patients and Methods Two analyses were conducted The first analysis compared R-CHOP to R-CVP as frontline agents for the treatment of FL and the second analysis included both untreated and relapsed patients. Results For both studies R-CVP was superior to R-CHOP when evaluating for complete response CR . Odds ratios were 95 CI in the first analysis and 95 CI in the second analysis. However for overall response CR Partial response PR .