tailieunhanh - Journal of Hematology & Oncology BioMed Central Research Open Access Radiation produces

Journal of Hematology & Oncology BioMed Central Research Open Access Radiation produces differential changes in cytokine profiles in radiation lung fibrosis sensitive and resistant mice Xiaoping Ao1, Lujun Zhao1, Mary A Davis1, David M Lubman2, Theodore S Lawrence1 and Feng-Ming Kong*1 Address: 1Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA and 2Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA Email: Xiaoping Ao - xpao@; Lujun Zhao - lujunzhao@; Mary A Davis - Madrad@; David M Lubman - dmlubman@; Theodore S Lawrence - tsl@; Feng-Ming Kong* - fengkong@ * Corresponding author Published: 2 February 2009 Journal of Hematology & Oncology 2009,. | BioMed Central Journal of Hematology Oncology Research Radiation produces differential changes in cytokine profiles in radiation lung fibrosis sensitive and resistant mice Xiaoping Ao1 Lujun Zhao1 Mary A Davis1 David M Lubman2 Theodore S Lawrence1 and Feng-Ming Kong 1 Open Access Address Department of Radiation Oncology University of Michigan Ann Arbor MI 48109 USA and 2Department of Surgery University of Michigan Ann Arbor MI 48109 USA Email Xiaoping Ao - xpao@ Lujun Zhao - lujunzhao@ Mary A Davis - Madrad@ David M Lubman - dmlubman@ Theodore S Lawrence - tsl@ Feng-Ming Kong - fengkong@ Corresponding author Published 2 February 2009 Received 8 August 2008 Journal of Hematology Oncology 2009 2 6 doi 1756-8722-2-6 Accepted 2 February 2009 This article is available from http content 2 1 6 2009 Ao et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Recent research has supported that a variety of cytokines play important roles during radiation-induced lung toxicity. The present study is designed to investigate the differences in early cytokine induction after radiation in sensitive C57BL 6 and resistant mice C3H . Results Twenty-two cytokines in the lung tissue homogenates bronchial lavage BAL fluids and serum from 3 6 12 24 hrs to I week after 12 Gy whole lung irradiation were profiled using a microsphere-based multiplexed cytokine assay. The majority of cytokines had similar baseline levels in C57BL 6 and C3H mice but differed significantly after radiation. Many including granulocyte colony-stimulating factor G-CSF interleukin-6 IL-6 and keratinocyte-derived chemokine KC were elevated significantly in specimens from both .