tailieunhanh - báo cáo khoa học: "Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis | BioMed Central Journal of Hematology Oncology Review Open Access Heat-shock proteins in infection-mediated inflammation-induced tumorigenesis Mark G Goldstein1 and Zihai Li 2 Address University of Connecticut 263 Farmington Avenue Farmington CT 06030 USA and 2Center for Immunotherapy of Cancer and Infectious Diseases University of Connecticut Health Center 263 Farmington Avenue Farmington CT 06030 USA Email Mark G Goldstein - Zihai Li - zli@ Corresponding author Published 30 January 2009 Received 15 December 2008 Journal of Hematology Oncology 2009 2 5 doi 1756-8722-2-5 Accepted 30 January 2009 This article is available from http content 2 1 5 2009 Goldstein and Li licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Inflammation is a necessary albeit insufficient component of tumorigenesis in some cancers. Infectious agents directly implicated in tumorigenesis have been shown to induce inflammation. This process involves both the innate and adaptive components of the immune system which contribute to tumor angiogenesis tumor tolerance and metastatic properties of neoplasms. Recently heatshock proteins have been identified as mediators of this inflammatory process and thus may provide a link between infection-mediated inflammation and subsequent cancer development. In this review the role of heat-shock proteins in infection-induced inflammation and carcinogenesis will be discussed. Introduction Since the time of Rudolf Ludwig Karl Virchow inflammation has been implicated as a necessary albeit insufficient component in tumorigenesis in some cancers 1 2 . Recent research has .