tailieunhanh - báo cáo khoa học: "Recent advances of novel targeted therapy in non-small cell lung cancer"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Recent advances of novel targeted therapy in non-small cell lung cancer | Journal of Hematology Oncology BioMed Central Open Access Review Recent advances of novel targeted therapy in non-small cell lung cancer Jed A Katzel Michael P Fanucchi and Zujun Li Address Department of Hematology and Oncology Saint Vincent s Hospital Manhattan and New York Medical College Valhalla NY USA Email Jed A Katzel - jkatzel@ Michael P Fanucchi - mfanucchi@ Zujun Li - zli@ Corresponding author Published 21 January 2009 Received 5 November 2008 Journal of Hematology Oncology 2009 2 2 doi 1756-8722-2-2 Accepted 21 January 2009 This article is available from http content 2 1 2 2009 Katzel et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Lung cancer is the leading cause of cancer deaths world-wide. Recent advances in cancer biology have led to the identification of new targets in neoplastic cells and the development of novel targeted therapies. At this time two targeted agents are approved by the FDA in advanced nonsmall cell lung cancer NSCLC the epidermal growth factor receptor EGFR tyrosine kinase inhibitor TKI erlotinib and the anitangiogenic bevacizumab. A third agent cetuximab which was recently shown to enhance survival when used with cisplatin and vinorelbine as first line therapy for advanced NSCLC will likely be approved by regulatory agencies. With more than 500 molecularly targeted agents under development the prospects of identifying novel therapies that benefit individual patients with lung cancer are bright. Introduction Lung cancer is the leading cause of cancer deaths for both men and women. It accounts for an estimated 15 of all new cancer cases diagnosed in the United States in 2008 and is responsible for .

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