tailieunhanh - Báo cáo y học: "Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancer"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancer. | Shanmugam et al. Journal of Hematology Oncology 2011 4 25 http content 4 1 25 JOURNAL OF HEMATOLOGY ONCOLOGY RESEARCH Open Access Evaluation of lymph node numbers for adequate staging of Stage II and III colon cancer r l . s u . Z-J I I r c k m I I ZI m 1 D V k z rt- D I_I I z I-2 l I I K S Z1 r I k I 2 ỉ D IX s - lzz z ZI 1 D I ĩ k Z14 I . ZZ z f ỉ lz5 7 ChandraKumar Shanmugam Robert B nines Nirag C Jhaia venKat R KaiKoori Din Zhang James A Posey Jr Harvey L Bumpers6 William E Grizzle1 7 Isam E Eltoum1 7 Gene P Siegal1 7 and Upender Manne1 7 Abstract Background Although evaluation of at least 12 lymph nodes LNs is recommended as the minimum number of nodes required for accurate staging of colon cancer patients there is disagreement on what constitutes an adequate identification of such LNs. Methods To evaluate the minimum number of LNs for adequate staging of Stage II and III colon cancer 490 patients were categorized into groups based on 1-6 7-11 12-19 and 20 LNs collected. Results For patients with Stage II or III disease examination of 12 LNs was not significantly associated with recurrence or mortality. For Stage II HR 95 CI but not for Stage III patients HR 95 CI examination of 20 LNs was associated with a reduced risk of recurrence within 2 years. However examination of 20 LNs had a 55 Stage II HR 95 CI and a 31 Stage III HR 95 CI decreased risk of mortality respectively. For each six additional LNs examined from Stage III patients there was a 19 increased probability of finding a positive LN parameter estimate p . For Stage II and III colon cancers there was improved survival and a decreased risK of recurrence with an increased number of LNs examined regardless of the cutoff-points. Examination of 7 or 12 LNs had similar outcomes but there were significant outcome benefits at the 20 cutoff-point only for Stage II patients. For Stage III patients examination of 6 .