tailieunhanh - Báo cáo y học: " Circulating osteopontin: a dual marker of bone destruction and angiogenesis in patients with multiple myeloma"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Circulating osteopontin: a dual marker of bone destruction and angiogenesis in patients with multiple myeloma. | Sfiridaki et al. Journal of Hematology Oncology 2011 4 22 http content 4 1 22 JOURNAL OF HEMATOLOGY ONCOLOGY LETTER TO THE EDITOR Open Access Circulating osteopontin a dual marker of bone destruction and angiogenesis in patients with multiple myeloma 12 3 3 4 2 Aikaterini Sfiridaki Spiros Miyakis Constantina Pappa George Tsirakis Athanasios Alegakis Vasileios Kotsis Efstathios Stathopoulos5 and Michael Alexandrakis 3 Abstract The matrix protein osteopontin has been shown to be a marker of osteoclastic activity in multiple myeloma patients as well as a regulator of angiogenesis. We measured serum levels of osteopontin in 50 untreated multiple myeloma patients in 25 also after treatment and examined the relation to markers of osteolytic and angiogenic activity. The median range of serum osteopontin was 85 5-232 in the patient group vs. 36 2-190 ng ml in the control group. Serum osteopontin levels were significantly higher in patients with advanced stage or grade of myeloma disease. All patients with serum osteopontin levels 100 ng ml had advanced stage II or III or high grade bone disease whereas stage I or low grade patients had serum osteopontin levels 100ng ml. Serum osteopontin levels significantly decreased after treatment. There was a positive correlation of osteopontin with the bone turnover marker N-terminal propeptide of procollagen type I NTx and the angiogenic markers vascular endothelial growth factor VEGF and bone marrow microvessel density r and respectively p . These results support osteopontin as a dual marker of bone destruction and angiogenic activity in myeloma patients. Osteopontin represents a useful biomarker for monitoring myeloma disease activity. To the Editor Osteopontin Opn is a non-collagenous matrix protein responsible for the migration and attachment of osteoclasts to mineral matrix of bone surfaces 1 . In vitro studies suggest that Opn and vascular endothelial growth factor VEGF cooperatively .