tailieunhanh - Báo cáo y học: "Lipooxygenase inhibition in osteoarthritis: a potential symptomatic and disease modifying effect"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Lipooxygenase inhibition in osteoarthritis: a potential symptomatic and disease modifying effect? | Available online http content 10 5 116 Editorial Lipooxygenase inhibition in osteoarthritis a potential symptomatic and disease modifying effect Maxime Dougados Paris-Descartes University Medicine Faculty UPRES-EA 4058 AP-HP Cochin Hospital Rheumatology B Department Paris France Corresponding author Maxime Dougados Published 19 September 2008 Arthritis Research Therapy 2008 10 116 doi ar2490 This article is online at http content 10 5 116 2008 BioMed Central Ltd See related research article by Sengupta et al. http content 10 4 R85 Abstract 5-Loxin is a compound extracted from an ancient herb that might be considered as a potent lipooxygenase inhibitor. The results observed in a preliminary trial suggest a highly intriguing clinically relevant symptomatic effect contrasting with a poor bioavailability of this compound. Moreover in this trial a statistically significant decrease in matrix metalloproteinase enzyme serum level suggests that in addition to the observed symptomatic effect such a compound might have a disease modifying effect in osteoarthritis. Further studies are required both to confirm the symptomatic efficacy and acceptable safety profile and to evaluate the potential chondromodulating effect of this compound. In the previous issue of Arthritis Research Therapy Sengupta and colleagues 1 report the results of a shortterm placebo randomized controlled trial evaluating both the symptomatic and biological effects of the compound 5-Loxin which is a gum resin extracted from an ancient herb. Despite the small sample size 25 patients per arm and the short duration of this trial 3 months the reported results are interesting and intriguing for several reasons. In the field of rheumatology most new therapeutic compounds are based on our knowledge of the pathophysiological pathways of the disease for example targeted therapies against cytokines such as tumor .

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