tailieunhanh - Báo cáo y học: "Stem cell transplantation for rheumatic autoimmune diseases"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Stem cell transplantation for rheumatic autoimmune diseases. | Available online http content 10 5 217 Review Stem cell transplantation for rheumatic autoimmune diseases Thomas Hugle1 and Jacob M van Laar2 1 Department of Rheumatology University of Basel Felix Platter Spital Burgfelderstrasse 101 4012 Basel Switzerland 2Musculoskeletal Research Group Institute of Cellular Medicine The Medical School Framlington Place Newcastle University Newcastle upon Tyne NE2 4HH UK Corresponding author Jacob M van Laar Published 10 October 2008 This article is online at http content 10 5 217 2008 BioMed Central Ltd Arthritis Research Therapy 2008 10 217 doi ar2486 Abstract Immunoablative therapy and hematopoietic stem cell transplantation HSCT is an intensive treatment modality aimed at resetting the dysregulated immune system of a patient with immunoablative therapy and allow outgrowth of a nonautogressive immune system from reinfused hematopoietic stem cells either from the patient autologous HSCT or a healthy donor allogeneic HSCT . HSCT has been shown to induce profound alterations of the immune system affecting B and T cells monocytes and natural killer and dendritic cells resulting in elimination of autoantibodyproducing plasma cells and in induction of regulatory T cells. Most of the available data have been collected through retrospective cohort analyses of autologous HSCT case series and translational studies in patients with refractory autoimmune diseases. Long-term and marked improvements of disease activity have been observed notably in systemic sclerosis systemic lupus erythematosus and juvenile idiopathic arthritis and treatment-related morbidity and mortality have improved due to better patient selection and modifications of transplant regimens. Treatment-related mortality has decreased to approximately 7 . Prospective randomised controlled clinical trials are ongoing or planned in systemic sclerosis systemic lupus erythematosus and several .