tailieunhanh - Báo cáo y học: "Effect of dsDNA binding to SmD-derived peptides on clinical accuracy in the diagnosis of systemic lupus erythematosus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Effect of dsDNA binding to SmD-derived peptides on clinical accuracy in the diagnosis of systemic lupus erythematosus. | Available online http content 9 4 R68 Research article Effect of dsDNA binding to SmD-derived peptides on clinical accuracy in the diagnosis of systemic lupus erythematosus Michael Mahler1 Aderajew Waka2 F Hiepe3 and Marvin J Fritzler4 Development and Production Dr Fooke Laboratorien MainstraBe 85 Neuss 41 469 Germany 2Charité-University of Medicine Berlin Internal Medicine Department of Rheumatology and Clinical Immunology German Rheumatism Research Centre of Berlin Department of Autoimmunology Charitéplatz 1 10117 Berlin Germany 3Medical Clinic for Rheumatology and Clinical Immunology Charité - Universitatsmedizin Berlin Charitéplatz 1 10117 Berlin Germany 4Department of Medicine and Biochemistry Molecular Biology Faculty of Medicine University of Calgary 3330 Hospital Dr. NW Calgary T2N 4N1 Canada Corresponding author Michael Mahler Received 28 Feb 2007 Revisions requested 11 Apr 2007 Revisions received 7 Jun 2007 Accepted 18 Jul 2007 Published 18 Jul 2007 Arthritis Research Therapy 2007 9 R68 doi ar2266 This article is online at http content 9 4 R68 2007 Mahler et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Systemic lupus erythematosus is characterized by antibodies to a variety of intracellular self-antigens such as dsDNA and Sm and these serve as hallmarks in the diagnosis of systemic autoimmune diseases. Several studies have shown that SmD1 and SmD3 synthetic peptides represent highly functional antigens for autoantibody detection and thus for diagnostic applications. The present study analysed the technical and clinical accuracy of an anti-SmD1 amino acids 83-119 and an anti-SmD3 amino acids 108-122 ELISA for the .