tailieunhanh - Báo cáo y học: "Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells. | Available online http content 10 4 R91 Research article Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells Xiangyang Huang1 2 Nan Shen1 2 Chunde Bao1 Yueying Gu1 Li Wu3 and Shunle Chen1 Shanghai Institute of Rheumatology Renji Hospital Shanghai Jiao Tong University School of Medicine Shan Dong Middle Road Shanghai 200001 PR China 2Molecular Rheumatology Laboratory Institute of Health Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine Chong Qing South Road Shanghai 200025 PR China 3Immunology Division The Walter and Eliza Hall Institute of Medical Research Royal Parade Parkville Victoria 3050 Australia Corresponding author Nan Shen shennand@ Received 22 Feb 2008 Revisions requested 8 Apr 2008 Revisions received 4 Aug 2008 Accepted 15 Aug 2008 Published 15 Aug 2008 Arthritis Research Therapy 2008 10 R91 doi ar2475 This article is online at http content 10 4 R91 2008 Huang et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Using oligonucleotide microarray many IFN-inducible genes have been found to be highly expressed in peripheral blood mononuclear cells PBMCs from most patients with systemic lupus erythematosus SLE . Among these IFN-inducible genes IFN-induced protein with tetratricopeptide repeats 4 IFIT4 is a novel gene whose function is unknown. Methods In this study we examined the role played by IFIT4 in monocyte differentiation and the correlation between IFIT4 expression and the clinical manifestation of SLE. To this end we used .