tailieunhanh - Báo cáo y học: "Expression and function of junctional adhesion molecule-C in human and experimental arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Expression and function of junctional adhesion molecule-C in human and experimental arthritis. | Available online http content 9 4 R65 Research article Expression and function of junctional adhesion molecule-C in human and experimental arthritis Gaby Palmer1 Nathalie Busso2 Michel Aurrand-Lions3 Dominique Talabot-Ayer1 Véronique Chobaz-Péclat2 Claudia Zimmerli3 Philippe Hammel3 Beat A Imhof3 and Cem Gabay1 Division of Rheumatology Department of Internal Medicine University Hospital 26 avenue Beau-Séjour 1211 Geneva 14 Switzerland and Department of Pathology and Immunology University of Geneva School of Medicine 1 rue Michel-Servet 1211 Geneva 4 Switzerland 2Division of Rheumatology Department of Medicine University Hospital Nestlé 05-5029 1011 Lausanne Switzerland 3Department of Pathology and Immunology University of Geneva School of Medicine 1 rue Michel-Servet 1 211 Geneva 4 Switzerland Contributed equally Corresponding author Cem Gabay Received 9 Mar 2007 Revisions requested 11 Apr 2007 Revisions received 11 Jun 2007 Accepted 5 Jul 2007 Published 5 Jul 2007 Arthritis Research Therapy 2007 9 R65 doi ar2223 This article is online at http content 9 4 R65 2007 Palmer et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Junctional adhesion molecule-C JAM-C is an adhesion molecule involved in transendothelial migration of leukocytes. In this study we examined JAM-C expression in the synovium and investigated the role of this molecule in two experimental mouse models of arthritis. JAM-C expression was investigated by reverse transcriptase-polymerase chain reaction and immunohistochemistry. The effects of a monoclonal anti-JAM-C antibody were assessed in antigen-induced arthritis AIA and K BxN serum transfer-induced arthritis. .