tailieunhanh - Báo cáo y học: "HLA class II DR and DQ genotypes and haplotypes associated with rheumatic fever among a clinically homogeneous patient"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: HLA class II DR and DQ genotypes and haplotypes associated with rheumatic fever among a clinically homogeneous patient . | Available online http content 9 3 R58 Research article HLA class II DR and DQ genotypes and haplotypes associated with rheumatic fever among a clinically homogeneous patient population of Latvian children Valda Stanevicha1 Jelena Eglite2 Dace Zavadska1 Arturs Sochnevs2 Ruta Shantere3 and Dace Gardovska1 1 Department of Pediatrics Riga Stradins University Vienibas gatve 45 Riga LV1004 Latvia 2Department of Imunology Riga Stradins University Dzirciema iela 1 6 Riga LV1007 Latvia 3Children Clinical University Hospital Vienibas gatve 45 Riga LV1004 Latvia Corresponding author Valda Stanevicha Received 15 Feb 2007 Revisions requested 23 Mar 2007 Revisions received 10 Apr 2007 Accepted 10 Jun 2007 Published 10 Jun 2007 Arthritis Research Therapy 2007 9 R58 doi ar2216 This article is online at http content 9 3 R58 2007 Stanevicha et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract The HLA system is being paid more and more attention because it is very significant in polymorphous immunological reactions. Several studies have suggested that genetic susceptibility to rheumatic fever RF and rheumatic heart disease RHD is linked to HLA class II alleles. We hypothesized that HLA class II associations within RHD may be more consistent if analysed amongst patients with a relatively homogeneous clinical outcome. A total of 70 RF patients under the age of 18 years were surveyed and analysed in Latvia. HLA genotyping of DQA1 DQB1 and DRB1 was performed using PCR with amplification with sequence-specific primers. We also used results from a previous study of DQB1 and DRB1 genotyping. In the RF patients HLA class II DQA1 0401 was found more .