tailieunhanh - Báo cáo y học: "B cells in Sjögren’s syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: B cells in Sjögren’s syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue. | Available online http content 9 4 218 Review B cells in Sjogren s syndrome indications for disturbed selection and differentiation in ectopic lymphoid tissue Arne Hansen1 Peter E Lipsky2 and Thomas Dorner1 1 Charite Centers CC 12 and 14 Departments of Medicine and Transfusion Medicine Charite-Universitatsmedizin Berlin Charite-Platz 01 10098 Berlin Germany 2Autoimmunity Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health Building 10 Bethesda MD 20892 USA Corresponding author Arne Hansen Published 6 August 2007 This article is online at http content 9 4 218 2007 BioMed Central Ltd Arthritis Research Therapy 2007 9 218 doi ar2210 Abstract Primary Sjogren s syndrome pSS is an autoimmune disorder characterized by specific pathological features. A hallmark of pSS is B-cell hyperactivity as manifested by the production of autoantibodies hypergammaglobulinemia formation of ectopic lymphoid structures within the inflamed tissues and enhanced risk of B-cell lymphoma. Changes in the distribution of peripheral B-cell subsets and differences in post-recombination processes of immunoglobulin variable region IgV gene usage are also characteristic features of pSS. Comparison of B cells from the peripheral blood and salivary glands of patients with pSS with regard to their expression of the chemokine receptors CXCR4 and CXCR5 and their migratory capacity towards the corresponding ligands CXCL1 2 and CXCL13 provide a mechanism for the prominent accumulation of CXCR4 CXCR5 memory B cells in the inflamed glands. Glandular B cells expressing distinct features of IgV light and heavy chain rearrangements re circulating B cells with increased mutations of cp transcripts in both CD27- and CD27 memory B-cell subsets and enhanced frequencies of individual peripheral B cells containing IgV heavy chain transcripts of multiple isotypes indicate disordered .