tailieunhanh - Báo cáo y học: "New classification of HLA-DRB1 alleles in rheumatoid arthritis susceptibility: a combined analysis of worldwide samples"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: New classification of HLA-DRB1 alleles in rheumatoid arthritis susceptibility: a combined analysis of worldwide samples. | Available online http content 10 1 R26 Open Access Research article New classification of HLA-DRB1 alleles in rheumatoid arthritis susceptibility a combined analysis of worldwide samples Thomas Barnetche1 Arnaud Constantin1 2 Alain Cantagrel2 3 Anne Cambon-Thomsen1 and Pierre-Antoine Gourraud1 4 Department of Epidemiology and Public Health UMR Inserm U 558 University Paul Sabatier Toulouse III Faculty of Medicine Purpan 37 Allées Jules Guesde Toulouse cedex 7 31073 France 2Rheumatology Department Larrey University Hospital 24 chemin de Pouvourville Toulouse cedex 9 31 059 France 3JE2510 University Paul Sabatier Toulouse III 11 8 route de Narbonne Toulouse 31062 cedex 9 France 4UF de Méthodologie de la recherche clinique Epidemioloy Unit Toulouse University Hospital 37 Allées Jules Guesde Toulouse cedex 7 31073 France Corresponding author Pierre-Antoine Gourraud gourraud@ Received 19 Sep 2007 Revisions requested 19 Oct 2007 Revisions received 12 Dec 2007 Accepted 28 Feb 2008 Published 28 Feb 2008 Arthritis Research Therapy 2008 10 R26 doi ar2379 This article is online at http content 10 1 R26 2008 Barnetche et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Rheumatoid arthritis RA is a complex polygenic disease of unknown etiology. HLA-DRB1 alleles encoding the shared epitope SE RAA amino acid pattern in positions 72 to 74 of the third hypervariable region of the DRp1 chain are associated with RA susceptibility. A new classification of HLA-DRB1 SE alleles has been developed by Tezenas du Montcel and colleagues to refine the association between HLA-DRB1 and RA. In the present study we used RA samples collected worldwide to investigate the .

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