tailieunhanh - Báo cáo y học: "Association of cerebrospinal fluid anti-ribosomal P protein antibodies with diffuse psychiatric/neuropsychological syndromes in systemic lupus erythematosus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Association of cerebrospinal fluid anti-ribosomal P protein antibodies with diffuse psychiatric/neuropsychological syndromes in systemic lupus erythematosus. | Available online http content 9 3 R44 Research article Association of cerebrospinal fluid anti-ribosomal P protein antibodies with diffuse psychiatric neuropsychological syndromes in systemic lupus erythematosus Shunsei Hirohata1 Yoshiyuki Arinuma2 Maki Takayama2 and Taku Yoshio3 Department of Rheumatology and Infectious Disease Kitasato University School of Medicine 1-15-1 Kitasato Sagamihara Kanagawa 228-8555 Japan 2Department of Internal Medicine Teikyo University School of Medicine 2-11-1 Kaga Itabashi-ku Tokyo 173-8605 Japan 3Division of Rheumatology and Clinical Immunology Jichi Medical University 3311-1 Yakushiji Shimotsuke Tochigi 329-0498 Japan Corresponding author Shunsei Hirohata shunsei@ Received 28 Jul 2006 Revisions requested 9 Aug 2006 Revisions received 5 Mar 2007 Accepted 2 May 2007 Published 2 May 2007 Arthritis Research Therapy 2007 9 R44 doi ar2184 This article is online at http content 9 3 R44 2007 Hirohata et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract We explored the relationship of antibodies to the whole ribosomal P proteins P0 P1 and P2 in cerebrospinal fluid CSF with diffuse psychiatric neuropsychological syndromes in systemic lupus erythematosus SLE . CSF samples were obtained from 71 SLE patients 52 patients with diffuse psychiatric neuropsychological syndromes diffuse NP-SLE and 19 patients with neurological syndromes or peripheral neuropathy focal NP-SLE as well as from 24 patients with non-inflammatory neurological disease. Immunoglobulin G IgG antibodies to the C-terminal 22-amino acid ribosomal P synthetic peptide anti-PC22 and those to purified bovine ribosomal P proteins P0 P1 and P2 .

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