tailieunhanh - Báo cáo y học: "Common interleukin-6 promoter variants associate with the more severe forms of distal interphalangeal osteoarthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Common interleukin-6 promoter variants associate with the more severe forms of distal interphalangeal osteoarthritis. | Available online http content 10 1 R21 Research article Common interleukin-6 promoter variants associate with the more severe forms of distal interphalangeal osteoarthritis Olli-Pekka Kamarainen1 Svetlana Solovieva2 Tapio Vehmas2 Katariina Luoma3 Hilkka Riihimaki2 Leena Ala-Kokko1 4 Minna Mannikko1 and Paivi Leino-Arjas2 1Collagen Research Unit Biocenter and Department of Medical Biochemistry and Molecular Biology University of Oulu 90220 Oulu Finland 2Centre of Expertise for Health and Work Ability Finnish Institute of Occupational Health 00250 Helsinki Finland 3Department of Radiology Helsinki University Central Hospital 00290 Helsinki Finland 4Connective Tissue Gene Tests Allentown PA 18103 USA Corresponding author Minna Mannikko Received 29 Aug 2007 Revisions requested 12 Oct 2007 Revisions received 20 Dec 2007 Accepted 8 Feb 2008 Published 8 Feb 2008 Arthritis Research Therapy 2008 10 R21 doi ar2374 This article is online at http content 10 1 R21 2008 Kamarainen et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The objective of this study was to investigate the relationship of the IL-6 promoter variants G-597A G-572C and G-174C rs1800797 rs1800796 and rs1800795 respectively which have been shown to affect both the transcription and secretion of IL-6 to symptomatic distal interphalangeal DIP osteoarthritis OA . Methods A total of 535 women aged 45 to 63 years were included. Radiographs of both hands were taken and each DIP joint was evaluated grade 0 to 4 for the presence of OA. Information on symptoms pain tenderness in each joint was collected by using a self-administered questionnaire. Symptomatic DIP .

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