tailieunhanh - Báo cáo y học: "Rutoside decreases human macrophage-derived inflammatory mediators and improves clinical signs in adjuvant-induced arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Rutoside decreases human macrophage-derived inflammatory mediators and improves clinical signs in adjuvant-induced arthritis. | Available online http content 10 1 R19 Open Access Research article Rutoside decreases human macrophage-derived inflammatory mediators and improves clinical signs in adjuvant-induced arthritis Tina Kauss1 2 Daniel Moynet1 Jerome Rambert1 Abir Al-Kharrat1 Stephane Brajot1 Denis Thiolat1 Rachid Ennemany3 Fawaz Fawaz2 and M Djavad Mossalayi1 Department of Immunology and Parasitology EA3677 School of Pharmacy Bordeaux 2 University 146 rue Léo Saignat 33076 Bordeaux France department of Galenic and Biopharmaceutics EA3677 School of Pharmacy Bordeaux 2 University 146 rue Léo Saignat 33076 Bordeaux France 3Eurotest 147 avenue de la Somme 33700 Merignac France Corresponding author M Djavad Mossalayi Received 11 Sep 2007 Revisions requested 14 Nov 2007 Revisions received 25 Jan 2008 Accepted 28 Jan 2008 Published 28 Jan 2008 Arthritis Research Therapy 2008 10 R19 doi ar2372 This article is online at http content 10 1 R19 2008 Kauss et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Dietary flavonols may play an important role in the adjunct therapy of chronic inflammation. The availability of therapeutic formulations of pentahydroxyflavone glycoside rutoside RU led us to investigate the ability of this molecule to modulate the release of various proinflammatory mediators from human activated macrophages in vitro and to ameliorate arthritic markers in a rat model. Methods RU was added simultaneously to human macrophages during their activation. Cells were then analyzed for inflammation-related gene expression using a specific array and cell supernatants were collected to measure inflammatory mediators. RU was also .

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