tailieunhanh - Báo cáo y học: "Recent developments in the immunobiology of rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Recent developments in the immunobiology of rheumatoid arthritis. | Available online http content 10 2 204 Review Recent developments in the immunobiology of rheumatoid arthritis Anna K Andersson Ching Li and Fionula M Brennan Kennedy Institute of Rheumatology Imperial College Faculty of Medicine 1 Aspenlea Road London W6 8LH UK Corresponding author Anna Andersson Published 14 March 2008 This article is online at http content 10 2 204 2008 BioMed Central Ltd Arthritis Research Therapy 2008 10 204 doi ar2370 Abstract Progress into the understanding of immunopathology in rheumatoid arthritis is reviewed in the present article with regard to pro-inflammatory cytokine production cell activation and recruitment and osteoclastogenesis. Studies highlight the potential importance of T helper 17 cells and regulatory T cells in driving and suppressing inflammation in rheumatoid arthritis respectively and highlight other potential T-cell therapeutic targets. The genetic associations of the HLA shared epitope alleles with antibodies to citrullinated peptides in rheumatoid arthritis patients indicate that T cells are providing help to B cells to produce autoantibodies and there is increasing evidence that these autoantibodies are pathogenic in rheumatoid arthritis. Introduction Rheumatoid arthritis RA is an autoimmune disease characterised by chronic inflammation of the joint. Although the precise pathogenesis of RA remains unclear T cells B cells macrophages neutrophils and synovial fibroblasts are central to the mechanisms of joint inflammation and disease progression. The genetic association of HLA-DR1 and HLA-DR4 with RA suggests that the disease is at least partially driven by T cells. The role of T cells has not however been conclusively demonstrated in the pathogenesis of RA - although the success of abatacept CTLA-4Ig in clinical trials 1 implies that rheumatoid T cells are important in driving the inflammatory process and thus T cells could be targeted in

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