tailieunhanh - Báo cáo y học: "Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results. | Available online http content 9 2 R41 Research article Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts 2-year clinical results Christian Ossendorf1 Christian Kaps2 Peter C Kreuz1 Gerd R Burmester2 Michael Sittinger2 and Christoph Erggelet1 Department of Traumotology and Orthopaedic Surgery University of Freiburg Hugstetter Strasse 55 79106 Freiburg Germany department of Rheumatology Charité Campus Mitte Charité - Universitatsmedizin Berlin Chariteplatz 1 10117 Berlin Germany Corresponding author Christian Kaps Received 21 Nov 2006 Revisions requested 31 Jan 2007 Revisions received 26 Mar 2007 Accepted 23 Apr 2007 Published 23 Apr 2007 Arthritis Research Therapy 2007 9 R41 doi ar2180 This article is online at http content 9 2 R41 2007 Ossendorf et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Autologous chondrocyte implantation ACI is an effective clinical procedure for the regeneration of articular cartilage defects. BioSeed -C is a second-generation ACI tissue engineering cartilage graft that is based on autologous chondrocytes embedded in a three-dimensional bioresorbable two-component gel-polymer scaffold. In the present prospective study we evaluated the short-term to mid-term efficacy of BioSeed-C for the arthrotomic and arthroscopic treatment of posttraumatic and degenerative cartilage defects in a group of patients suffering from chronic posttraumatic and or degenerative cartilage lesions of the knee. Clinical outcome was assessed in 40 patients with a 2-year clinical follow-up before implantation and at 3 6 12 .