tailieunhanh - Báo cáo y học: "Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis. | Available online http content 10 1 R14 Research article Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis Anthony J Milici1 Elizabeth M Kudlacz2 Laurent Audoly3 Samuel Zwillich2 and Paul Changelian4 1Pfizer Global Research and Development MS 8220-2235 Groton CT 06340 USA 2Pfizer Global Research and Development 50 Pequot Ave New London CT 06320 USA 3Merck Research Laboratories West Point PA 19486 USA 41009 Glenhill Drive Northville MI 48167 USA Contributed equally Corresponding author Anthony J Milici Received 11 Sep 2007 Revisions requested 12 Oct 2007 Revisions received 24 Jan 2008 Accepted 30 Jan 2008 Published 30 Jan 2008 Arthritis Research Therapy 2008 10 R14 doi ar2365 This article is online at http content 10 1 R14 2008 Milici et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction CP-690550 is a small molecule inhibitor of Janus kinase 3 JAK3 a critical enzyme in the signaling pathway of multiple cytokines interleukin IL -2 -7 -15 and -21 that are important in various T cell functions including development activation and homeostasis. The purpose of this study was to evaluate CP-690550 in murine collagen-induced CIA and rat adjuvant-induced AA models of rheumatoid arthritis RA . Methods CIA and AA were induced using standard protocols and animals received the JAK3 inhibitor via osmotic mini-pump infusion at doses ranging from mg kg day following disease induction. Arthritis was assessed by clinical scores in the CIA models and paw swelling monitored using a plethysmometer in the AA model until study conclusion at which time animals were killed and .