tailieunhanh - Báo cáo y học: "Local adherent technique for transplanting mesenchymal stem cells as a potential treatment of cartilage defect"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Local adherent technique for transplanting mesenchymal stem cells as a potential treatment of cartilage defect. | Available online http content 10 4 R84 Research article Local adherent technique for transplanting mesenchymal stem cells as a potential treatment of cartilage defect Hideyuki Koga1 Masayuki Shimaya1 Takeshi Muneta1 2 Akimoto Nimura1 Toshiyuki Morito1 Masaya Hayashi1 Shiro Suzuki1 Young-Jin Ju1 Tomoyuki Mochizuki3 and Ichiro Sekiya3 Section of Orthopedic Surgery Graduate School Tokyo Medical and Dental University 1-5-45 Yushima Bunkyo-ku Tokyo 113-8519 Japan 2Global Center of Excellence Program International Research Center for Molecular Science in Tooth and Bone Diseases Tokyo Medical and Dental University 1-5-45 Yushima Bunkyo-ku Tokyo 113-8519 Japan 3Section of Cartilage Regeneration Graduate School Tokyo Medical and Dental University 1-5-45 Yushima Bunkyo-ku Tokyo 113-8519 Japan Corresponding author Ichiro Sekiya Received 17 Mar 2008 Revisions requested 10 Apr 2008 Revisions received 23 Jul 2008 Accepted 29 Jul 2008 Published 29 Jul 2008 Arthritis Research Therapy 2008 10 R84 doi ar2460 This article is online at http content 10 4 R84 2008 Koga et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Current cell therapy for cartilage regeneration requires invasive procedures periosteal coverage and scaffold use. We have developed a novel transplantation method with synovial mesenchymal stem cells MSCs to adhere to the cartilage defect. Methods For ex vivo analysis in rabbits the cartilage defect was faced upward filled with synovial MSC suspension and held stationary for to 15 minutes. The number of attached cells was examined. For in vivo analysis in rabbits an autologous synovial MSC suspension was placed on