tailieunhanh - Báo cáo y học: "Serum keratan sulfate transiently increases in the early stage of osteoarthritis during strenuous running of rats: protective effect of intraarticular hyaluronan injection"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Serum keratan sulfate transiently increases in the early stage of osteoarthritis during strenuous running of rats: protective effect of intraarticular hyaluronan injection. | Available online http content 10 1 R13 Research article Serum keratan sulfate transiently increases in the early stage of osteoarthritis during strenuous running of rats protective effect of intraarticular hyaluronan injection Tao Tang1 Takeshi Muneta1 2 Young-Jin Ju1 Akimoto Nimura1 Kyosuke Miyazaki3 Hiroyuki Masuda3 Tomoyuki Mochizuki4 and Ichiro Sekiya4 Section of Orthopedic Surgery Graduate School Tokyo Medical and Dental University 1-5-45 Yushima Bunkyo-ku Tokyo 113-8519 Japan 2Center of Excellence Program of Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone Tokyo Medical and Dental University 1-5-45 Yushima Bunkyo-ku Tokyo 113-8519 Japan 3Department of Pharmaceuticals Information Seikagaku Corporation 1-6-1 Marunouchi Chiyoda-ku Tokyo 113-8519 Japan 4Section of Cartilage Regeneration Graduate School Tokyo Medical and Dental University 1-5-45 Yushima Bunkyo-ku Tokyo 113-8519 Japan Corresponding author Ichiro Sekiya Received 26 Nov 2007 Revisions requested 21 Dec 2007 Revisions received 16 Jan 2008 Accepted 30 Jan 2008 Published 30 Jan 2008 Arthritis Research Therapy 2008 10 R13 doi ar2363 This article is online at http content 10 1 R13 2008 Tang et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Osteoarthritis is influenced by genetic and environment factors including mechanical stress however the relationship between running and the development of osteoarthritis remains a matter of controversy. We investigated whether osteoarthritic change could be obtained in a rat strenuous running model whether serum keratan sulfate in rats could be detected by HPLC and was associated with .