tailieunhanh - Báo cáo y học: "Altered fractalkine cleavage results in an organ-specific 17 kDa fractalkine fragment in salivary glands of NOD mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Altered fractalkine cleavage results in an organ-specific 17 kDa fractalkine fragment in salivary glands of NOD mice. | Available online http content 10 4 114 Editorial Altered fractalkine cleavage results in an organ-specific 17 kDa fractalkine fragment in salivary glands of NOD mice Nicolas Delaleu1 and Roland Jonsson1 2 3 1 Broegelmann Research Laboratory The Gade Institute University of Bergen Haukelandsveien 28 Bergen 5021 Norway 2Department of Rheumatology Haukeland University Hospital Bergen Jonas Liesvei 65 Bergen 5021 Norway 3Department of Otolaryngology Head and Neck Surgery Haukeland University Hospital Bergen Jonas Liesvei 65 Bergen 5021 Norway Corresponding author Roland Jonsson . Published 31 July 2008 Arthritis Research Therapy 2008 10 114 doi ar2458 This article is online at http content 10 4 114 2008 BioMed Central Ltd See related research by Wildenberg et al. http content 10 3 R69 Abstract Sjogren s syndrome is a rheumatic disease in which the salivary and lacrimal glands are the principal targets of a pathological autoimmune reaction. Previous studies in mice indicated that delayed organogenesis and aberrant cell physiology followed by an increase in acinar cell apoptosis precede chronic focal inflammation in the salivary glands and the manifestation of impaired exocrine gland secretion. In a recent study by Wildenberg and colleagues the authors report aberrant proteolytic activity in the salivary glands of non-obese diabetic mice and the generation of a unique organ-specific 17 kDa fragment of the chemokine and adhesion molecule fractalkine. In the previous issue of Arthritis Research Therapy aberrant proteolytic activity in the salivary glands of non-obese diabetic NOD mice with spontaneous experimental Sjogren s syndrome SS was reported 1 . SS is a rather common systemic autoimmune disease characterized by exocrine gland inflammation and impaired glandular function 2 . The NOD strain has become a commonly used spontaneous model for SS in which several .