tailieunhanh - Báo cáo y học: "Faecal blood loss with aspirin, nonsteroidal anti-inflammatory drugs and cyclo-oxygenase-2 selective inhibitors: systematic review of randomized trials using autologous chromium-labelled erythrocytes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Faecal blood loss with aspirin, nonsteroidal anti-inflammatory drugs and cyclo-oxygenase-2 selective inhibitors: systematic review of randomized trials using autologous chromium-labelled erythrocytes. | Available online http content 10 1 R7 Research article Faecal blood loss with aspirin nonsteroidal anti-inflammatory drugs and cyclo-oxygenase-2 selective inhibitors systematic review of randomized trials using autologous chromium-labelled erythrocytes R Andrew Moore Sheena Derry and Henry J McQuay Pain Research Nuffield Department of Anaesthetics University of Oxford Oxford Radcliffe Hospitals The Churchill Headington Oxford OX3 7LJ UK Corresponding author R Andrew Moore Received 20 Jul 2007 Revisions requested 27 Sep 2007 Revisions received 10 Oct 2007 Accepted 17 Jan 2008 Published 17 Jan 2008 Arthritis Research Therapy 2008 10 R7 doi 1 ar2355 This article is online at http content 10 1 R7 2008 Moore et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Faecal blood loss has been measured using autologous erythrocytes labelled with radioactive chromium for several decades using generally similar methods. We conducted a systematic review of studies employing this technology to determine the degree of blood loss associated with use of aspirin nonsteroidal anti-inflammatory drugs NSAIDs and cyclo-oxygenase-2 selective inhibitors coxibs . Methods A systematic search of PubMed and the Cochrane Library to December 2006 was conducted to identify randomized trials in which treatment with aspirin NSAIDs or coxibs was continued for at least 7 days and with at least 7 days of washout for crossover trials. Rates of faecal blood loss associated with these agents were determined in the randomized trials identified. Comparators were placebo active or no treatment. Outcomes of interest were mean daily faecal blood loss and .

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