tailieunhanh - Báo cáo y học: "The renal metallothionein expression profile is altered in human lupus nephriti"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The renal metallothionein expression profile is altered in human lupus nephritis. | Available online http content 10 4 R76 Research article The renal metallothionein expression profile is altered in human lupus nephritis Mikkel Faurschou1 Milena Penkowa2 Claus Bogelund Andersen3 Henrik Starklint4 and Soren Jacobsen1 Department of Rheumatology The National University Hospital Rigshospitalet 9 Blegdamsvej DK-2100 Copenhagen Denmark 2Section of Neuroprotection Faculty of Health Sciences University of Copenhagen 3 Blegdamsvej DK-2200 Copenhagen Denmark department of Pathology The National University Hospital Rigshospitalet 9 Blegdamsvej DK-2100 Copenhagen Denmark department of Pathology Vejle Hospital 25 Kabbeltoft DK-7100 Vejle Denmark Corresponding author Mikkel Faurschou mfaurschou@ Received 17 Mar 2008 Revisions requested 21 Apr 2008 Revisions received 30 May 2008 Accepted 6 Jul 2008 Published 6 Jul 2008 Arthritis Research Therapy 2008 10 R76 doi ar2450 This article is online at http content 10 4 R76 2008 Faurschou et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Metallothionein MT isoforms I II are polypeptides with potent antioxidative and anti-inflammatory properties. In healthy kidneys MT-I II have been described as intracellular proteins of proximal tubular cells. The aim of the present study was to investigate whether the renal MT-I II expression profile is altered during lupus nephritis. Methods Immunohistochemistry was performed on renal biopsies from 37 patients with lupus nephritis. Four specimens of healthy renal tissue served as controls. Clinicopathological correlation studies and renal survival analyses were performed by means of standard statistical methods. Results Proximal tubules .