tailieunhanh - Báo cáo y học: "Diagnosis of periarticular osteoporosis in rheumatoid arthritis using digital X-ray radiogrammetry"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Diagnosis of periarticular osteoporosis in rheumatoid arthritis using digital X-ray radiogrammetry. | Available online http content 10 1 103 Editorial Diagnosis of periarticular osteoporosis in rheumatoid arthritis using digital X-ray radiogrammetry Joachim Bottcher and Alexander Pfeil Institute of Diagnostic and Interventional Radiology Friedrich-Schiller-University Jena Erlanger Allee 07747 Jena Germany Corresponding author Joachim Bottcher Published 24 January 2008 Arthritis Research Therapy 2008 10 103 doi ar2352 This article is online at http content 10 1 103 2008 BioMed Central Ltd See related research article by Hoff et al. http content 9 4 R81 Abstract Osteoporosis can manifest in two ways in rheumatoid arthritis generalized bone loss which may result from immobility the inflammatory process per se and or treatments such as steroids and periarticular demineralization which is probably due to local release of inflammatory agents. Digital X-ray radiogrammetry DXR is an effective and sensitive modality for monitoring periarticular osteoporosis which is among the earliest features of rheumatoid arthritis preceding bone erosions. DXR is a promising technique which can provide quantitative data that allow early diagnosis. During the course of rheumatoid arthritis it can be deployed in combination with established X-ray scoring methods to inform decisions regarding the optimal therapy to prevent joint destruction. Introduction In a well documented and extensive study of peripheral bone loss in established rheumatoid arthritis RA Hoff and colleagues 1 evaluated bone loss in the hand using digital X-ray radiogrammetry DXR and dual energy X-ray absorptiometry DXA . They compared peripheral demineralization with central bone loss quantified by axial DXA measurements at the lumbar spine and femoral neck considering disease duration over an observation period of 2 years. This carefully conducted study revealed significant peripheral hand bone loss estimated by