tailieunhanh - Báo cáo y học: "Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. | Available online http content 10 4 R73 Research article Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis Pei Jin1 Juan Zhang1 Percy F Sumariwalla2 Irene Ni1 Brett Jorgensen1 Damian Crawford2 Suzanne Phillips3 Marc Feldmann2 H Michael Shepard1 and Ewa M Paleolog2 1Receptor BioLogix Inc. Palo Alto CA 94303 USA 2Kennedy Institute of Rheumatology Faculty of Medicine Imperial College London London W6 8LH UK 3Gentris Corporation Morrisville NC 27560 USA Corresponding author Pei Jin pjin@ Received 13 May 2008 Revisions requested 9 Jun 2008 Revisions received 25 Jun 2008 Accepted 1 Jul 2008 Published 1 Jul 2008 Arthritis Research Therapy 2008 10 R73 doi ar2447 This article is online at http content 10 4 R73 2008 Jin et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Despite the advent of biological therapies for the treatment of rheumatoid arthritis there is a compelling need to develop alternative therapeutic targets for nonresponders to existing treatments. Soluble receptors occur naturally in vivo such as the splice variant of the cell surface receptor for vascular endothelial growth factor VEGF - a key regulator of angiogenesis in rheumatoid arthritis. Bioinformatics analyses predict that the majority of human genes undergo alternative splicing generating proteins - many of which may have regulatory functions. The objective of the present study was to identify alternative splice variants ASV from cell surface receptor genes and to determine whether the novel proteins encoded exert therapeutic activity in an in vivo model of arthritis. Methods To .