tailieunhanh - Báo cáo y học: "CD47 associates with alpha 5 integrin and regulates responses of human articular chondrocytes to mechanical stimulation in an in vitro model"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: CD47 associates with alpha 5 integrin and regulates responses of human articular chondrocytes to mechanical stimulation in an in vitro model. | Available online http content 10 1 R4 Research article CD47 associates with alpha 5 integrin and regulates responses of human articular chondrocytes to mechanical stimulation in an in vitro model Mahmoud Orazizadeh1 3 Herng Sheng Lee2 3 Bianca Groenendijk3 S Jane Millward Sadler3 Malcolm O Wright3 Frederik P Lindberg4 and Donald M Salter3 5 Department of Anatomical Sciences Medical School Ahwaz Jondishapour University of Medical Sciences Ahwaz Iran department of Pathology Tri-Service General Hospital and National Defense Medical Center Chenggong Rd Neihu District Taipei City 114 Taiwan 3The Division of Pathology School of Molecular and Clinical Medicine College of Medicine and Veterinary Medicine Edinburgh University 47 Little France Crescent Edinburgh EH16 4TJ UK 4Infectious Diseases Division Department of Medicine Washington University School of Medicine 660 S. Euclid Ave St. Louis MO 63110 USA 5Centre for Inflammation Research Queen s Medical Research Institute 47 Little France Crescent Edinburgh EH16 4TJ UK Corresponding author Donald M Salter Received 26 Jun 2007 Revisions requested 6 Sep 2007 Revisions received 2 Dec 2007 Accepted 10 Jan 2008 Published 10 Jan 2008 Arthritis Research Therapy 2008 10 R4 doi 1 ar2350 This article is online at http content 10 1 R4 2008 Orazizadeh et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Background Recent studies provide evidence of roles for integrins in mechanical signalling in bone and cartilage. Integrin signalling is modulated by various mechanisms including interaction with other transmembrane proteins. We aimed to identify whether one such protein .