tailieunhanh - Báo cáo y học: "The human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis. | Available online http content 10 3 R67 Open Access Research article The human anti-IL-1 p monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis Rieke Alten1 Hermann Gram2 Leo A Joosten3 Wim B van den Berg3 Joachim Sieper4 Siegfrid Wassenberg5 Gerd Burmester6 Piet van Riel7 Maria Diaz-Lorente8 Gerardus JM Bruin8 Thasia G Woodworth8 Christiane Rordorf8 Yannik Batard8 Andrew M Wright8 and Thomas Jung8 department of Internal Medicine II Rheumatology Schlosspark-Klinik Teaching Hospital Charité University Medicine Berlin Heubnerweg D-1 4059 Berlin Germany 2Novartis Institutes of Biomedical Research Basel CH-4002 Basel Switzerland 3Rheumatology Research and Advanced Therapeutics Radboud University Nijmegen Medical Centre Nijmegen 6500 HB The Netherlands department of Rheumatology Klinikum Benjamin Franklin Hindenburgdamm D-12200 Berlin Germany department of Rheumatology Evangelisches Fachkrankenhaus RosenstraBe D-40882 Ratingen Germany 6Department of Rheumatology Charité Charitéplatz D-10117 Berlin Germany department of Rheumatology University Medical Center St Radboud Nijmegen 6500 HB The Netherlands 8Novartis Exploratory Development Werk St. Johann Forum 1 CH-4002 Basel Switzerland Corresponding author Thomas Jung Received 2 Jan 2008 Revisions requested 25 Feb 2008 Revisions received 16 Apr 2008 Accepted 5 Jun 2008 Published 5 Jun 2008 Arthritis Research Therapy 2008 10 R67 doi ar2438 This article is online at http content 10 3 R67 2008 Alten et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction IL-1p is a proinflammatory cytokine .

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