tailieunhanh - Báo cáo y học: "Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease. | Available online http content 10 1 201 Review Activator protein 1 Fos Jun functions in inflammatory bone and skin disease Rainer Zenz1 2 Robert Eferl1 2 Clemens Scheinecker3 Kurt Redlich3 Josef Smolen3 Helia B Schonthaler4 Lukas Kenner1 2 5 Erwin Tschachler6 and Erwin F Wagner41 1 Ludwig Boltzmann Institute for Cancer Research Wahringer Strasse 13a A-1090 Vienna Austria 2Center for Biomolecular Medicine and Pharmacy Medical University of Vienna Wahringer Strasse 13a A-1090 Vienna Austria 3Division of Rheumatology Medical University of Vienna Wahringer Gurtel 18-20 A-1090 Vienna Austria 4Research Institute of Molecular Pathology Dr. Bohr-Gasse 7 A-1030 Vienna Austria 5Clinical Institute of Pathology Medical University of Vienna Wahringer Gurtel 18-20 A-1090 Vienna Austria 6Department of Dermatology Medical University of Vienna Wahringer Gurtel 18-20 A-1090 Vienna Austria Present address Cancer Cell Biology Program Spanish National Cancer Center CNIO Melchor Fernandez Almagro 3 E-28029 Madrid Spain Corresponding author Erwin F Wagner wagner@ Published 18 January 2008 This article is online at http content 10 1 201 2008 BioMed Central Ltd Arthritis Research Therapy 2008 10 201 doi ar2338 Abstract Activator protein 1 AP-1 Fos Jun is a transcriptional regulator composed of members of the Fos and Jun families of DNA binding proteins. The functions of AP-1 were initially studied in mouse development as well as in the whole organism through conventional transgenic approaches but also by gene targeting using knockout strategies. The importance of AP-1 proteins in disease pathways including the inflammatory response became fully apparent through conditional mutagenesis in mice in particular when employing gene inactivation in a tissue-specific and inducible fashion. Besides the well-documented roles of Fos and Jun proteins in oncogenesis where these genes can function both as tumor promoters or tumor suppressors .