tailieunhanh - Báo cáo y học: "A second-generation autologous chondrocyte implantation approach to the treatment of focal articular cartilage defects"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: A second-generation autologous chondrocyte implantation approach to the treatment of focal articular cartilage defects. | Available online http content 9 5 109 Commentary A second-generation autologous chondrocyte implantation approach to the treatment of focal articular cartilage defects Rocky S Tuan Cartilage Biology and Orthopaedics Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health Department of Health and Human Services Bethesda Maryland 20892 USA Corresponding author Rocky S Tuan tuanr@ Published 31 October 2007 This article is online at http content 9 5 109 2007 BioMed Central Ltd. Arthritis Research Therapy 2007 9 109 doi ar2310 Abstract Autologous chondrocyte implantation ACI is the most widely used cell-based surgical procedure for the repair of articular cartilage defects. Challenges to successful ACI outcomes include limitation in defect size and geometry as well as inefficient cell retention. Second-generation ACI procedures have thus focused on developing three-dimensional constructs using native and synthetic biomaterials. Clinically significant and satisfactory results from applying autologous chondrocytes seeded in fibrin within a biodegradable polymeric material were recently reported. In the future third-generation cell-based articular cartilage repair should focus on the use of chondroprogenitor cells and biofunctionalized biomaterials for more extensive and permanent repair. Introduction The hyaline articular cartilage protects the bones of diarthrodial joints from forces associated with load bearing friction and impact. Despite its viscoelastic properties and remarkable mechanical durability once articular cartilage is injured it has very limited capacities for self-repair. In fullthickness cartilage injuries in which there is damage to the chondral layer and subchondral bone plate blood vessel rupture and hematoma formation are seen at the injury site. Chondroprogenitor cells derived from the bone marrow migrate to the lesion and initiate a .