tailieunhanh - Báo cáo y học: " Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration: lessons from the osteoarthritic experience"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration: lessons from the osteoarthritic experience. | Available online http content 9 6 110 Editorial Is interleukin-1 a good target for therapeutic intervention in intervertebral disc degeneration lessons from the osteoarthritic experience Philippe Goupille1 Denis Mulleman1 and Xavier Chevalier2 1CHRU de Tours Université Franpois Rabelais INSERM Centre d investigation clinique 202 Tours France 2University Hospital Créteil France Corresponding author Philippe Goupille goupille@ Published 21 November 2007 Arthritis Research Therapy 2007 9 110 doi ar2324 This article is online at http content 9 6 110 2007 BioMed Central Ltd See related research article by Le Maitre et al. http content 9 4 R77 Abstract IL-1 plays a key role in disc degeneration and could be a valid target for inhibiting this process. IL-1 receptor antagonist IL-1ra might be a good candidate to inhibit IL-1 activity. However many questions need to be addressed before contemplating therapy in humans. IL-1 blockade is also a great challenge in osteoarthritis and results from animal models suggest that IL-1ra may have beneficial effects. The clinical benefit of a local injection of IL-1ra in knee osteoarthritis may be limited by the antagonist s short half-life. Further studies with longer-lasting antagonists are needed to explore this new therapeutic approach. A better understanding of the pathogenesis of inflammatory arthritis has led to the development and subsequent successful use in humans of biopharmaceuticals blocking for example tumor necrosis factor TNF a CD-20 IL-1 and IL-6 and T-cell co-stimulating factors CTLA-4 . No targeted treatments are available however for degenerative rheumato-logical diseases such as low back pain LBP due to intervertebral disc IVD degeneration or knee osteoarthritis OA . This deficiency may be due in part to our limited understanding of the pathogenesis of these diseases a better understanding of the pathogenesis of IVD .