tailieunhanh - Báo cáo y học: "New therapies in fibromyalgia"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: New therapies in fibromyalgia. | Available online http content 8 4 212 Review Biology and therapy of fibromyalgia New therapies in fibromyalgia Lesley M Arnold Women s Health Research Program University of Cincinnati College of Medicine Piedmont Avenue Cincinnati Ohio 45219 USA Corresponding author Lesley M Arnold Published 1 June 2006 This article is online at http content 8 4 212 2006 BioMed Central Ltd Arthritis Research Therapy 2006 8 212 doi ar1971 Abstract Fibromyalgia is a chronic musculoskeletal pain condition that predominately affects women. Although fibromyalgia is common and associated with substantial morbidity and disability there are no US Food and Drug Administration-approved treatments. However progress has been made in identifying pharmacological and non-pharmacological treatments for fibromyalgia. Recent pharmacological treatment studies have focused on selective serotonin and norepinephrine reuptake inhibitors which enhance serotonin and norepinephrine neurotransmission in the descending pain pathways and lack many of the adverse side effects associated with tricyclic medications. Promising results have also been reported for medications that bind to the a2S subunit of voltage-gated calcium channels resulting in decreased calcium influx at nerve terminals and subsequent reduction in the release of several neurotransmitters thought to play a role in pain processing. There is also evidence to support exercise cognitive behavioral therapy education and social support in the management of fibromyalgia. It is likely that many patients would benefit from combinations of pharmacological and non-pharmacological treatments but more study is needed. Introduction This review focuses on recent randomized controlled studies of pharmacological and non-pharmacological therapies for fibromyalgia. Clinical recommendations for the management of fibromyalgia will be based on the available evidence from these trials. .