tailieunhanh - Báo cáo khoa học: " CyberKnife® radiosurgery in the treatment of complex skull base tumors: analysis of treatment planning parameters"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " CyberKnife® radiosurgery in the treatment of complex skull base tumors: analysis of treatment planning parameters. | Radiation Oncology BioMed Central Open Access Methodology CyberKnife radiosurgery in the treatment of complex skull base tumors analysis of treatment planning parameters Sean P Collins12 Nicholas D Coppa11 Ying Zhang3 Brian T Collins2 Donald A McRae2 and Walter C Jean 1 2 Address Department of Neurosurgery Georgetown University Hospital USA 2Department of Radiation Oncology Georgetown University Hospital USA and 3Biostatistics Unit Lombardi Comprehensive Cancer Center Georgetown University Medical Center USA Email Sean P Collins - mbppkia@ Nicholas D Coppa - coppan@ Ying Zhang - yz9@ Brian T Collins - collinsb@ Donald A McRae - mcraed@ Walter C Jean - wcj4@ Corresponding author fEqual contributors Published 16 December 2006 Radiation Oncology 2006 1 46 doi 1748-717X-1-46 Received 05 August 2006 Accepted 16 December 2006 This article is available from http content 1 1 46 2006 Collins et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Tumors of the skull base pose unique challenges to radiosurgical treatment because of their irregular shapes proximity to critical structures and variable tumor volumes. In this study we investigate whether acceptable treatment plans with excellent conformity and homogeneity can be generated for complex skull base tumors using the Cyberknife radiosurgical system. Methods At Georgetown University Hospital from March 2002 through May 2005 the CyberKnife was used to treat 80 patients with 82 base of skull lesions. Tumors were classified as simple or complex based on their proximity to adjacent critical structures. All planning and treatments were performed by the