tailieunhanh - Báo cáo y học: "Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis: validation of a minimally invasive ultrasound-guided synovial biopsy procedure"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis: validation of a minimally invasive ultrasound-guided synovial biopsy procedure. | Available online http content 9 5 R101 Research article Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis validation of a minimally invasive ultrasound-guided synovial biopsy procedure Carlo Alberto Scirè1 Oscar Epis1 Veronica Codullo1 Frances Humby2 Patrizia Morbini3 Antonio Manzo2 Roberto Caporali1 Costantino Pitzalis2 and Carlomaurizio Montecucco1 1Chair and Division of Rheumatology University of Pavia Fondazione IRCCS Policlinico San Matteo Piazzale Golgi 12 I 27100 Pavia Italy 2Centre for Experimental Medicine and Rheumatology 2nd floor John Vane Science Centre William Harvey Research Institute St Bartholomew s and Royal London School of Medicine. Charter House Square London EC1M6BQ UK 3Department of Pathology University of Pavia Fondazione IRCCS Policlinico San Matteo Piazzale Golgi 12 I 27100 Pavia Italy Corresponding author Carlomaurizio Montecucco montecucco@ Received 11 Jul 2007 Revisions requested 23 Aug 2007 Revisions received 4 Sep 2007 Accepted 28 Sep 2007 Published 28 Sep 2007 Arthritis Research Therapy 2007 9 R101 doi ar2302 This article is online at http content 9 5 R101 2007 Scirè et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract The aim of the present study was to perform an immunohistological assessment of the synovial tissue from involved small joints in rheumatoid arthritis RA and to explore the reliability of a mini-invasive ultrasound US -guided technique of small joint synovial biopsy for the histopathological assessment. Synovial tissue collected during arthrotomic surgery of small joints in nine patients served as the gold standard for the validation of the .