tailieunhanh - Báo cáo y học: "Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-β/bone morphogenic protein signalling"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-β/bone morphogenic protein signalling. | Available online http content 9 5 R100 Research article Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling WNT and transforming growth factor-p bone morphogenic protein signalling Blair Hopwood1 2 Anna Tsykin3 David M Findlay2 4 and Nicola L Fazzalari1 2 5 1 Division of Tissue Pathology Institute of Medical Veterinary Science Frome Road Adelaide South Australia 5000 Australia 2Hanson Institute Frome Road Adelaide South Australia 5000 Australia 3School of Mathematics University of Adelaide North Terrace Adelaide South Australia 5005 Australia 4Discipline of Orthopaedics Trauma University of Adelaide North Terrace Adelaide South Australia 5005 Australia 5Discipline of Pathology University of Adelaide North Terrace Adelaide South Australia 5005 Australia Corresponding author Nicola L Fazzalari Received 11 Jul 2007 Revisions requested 10 Aug 2007 Revisions received 10 Sep 2007 Accepted 27 Sep 2007 Published 27 Sep 2007 Arthritis Research Therapy 2007 9 R100 doi ar2301 This article is online at http content 9 5 R100 2007 Hopwood et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Osteoarthritis OA is characterized by alterations to subchondral bone as well as articular cartilage. Changes to bone in OA have also been identified at sites distal to the affected joint which include increased bone volume fraction and reduced bone mineralization. Altered bone remodelling has been proposed to underlie these bone changes in OA. To investigate the molecular basis for these changes we performed microarray gene expression profiling of bone obtained at autopsy from individuals with no .