tailieunhanh - Báo cáo khoa học: " Local tumor control and toxicity in HIV-associated anal carcinoma treated with radiotherapy in the era of antiretroviral therapy"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " Local tumor control and toxicity in HIV-associated anal carcinoma treated with radiotherapy in the era of antiretroviral therapy. | Radiation Oncology BioMed Central Research Local tumor control and toxicity in HIV-associated anal carcinoma treated with radiotherapy in the era of antiretroviral therapy Christoph Oehler-Janne1 Burkhardt Seifert2 Urs M Lutolf1 and I Frank Ciernik 1 Open Access Address Radiation Oncology Zurich University Hospital Switzerland and 2Department for Social- and Preventive Medicine Biostatistics University of Zurich Zurich Switzerland Email Christoph Oehler-Janne - Burkhardt Seifert - seifert@ Urs M Lutolf- I Frank Ciernik - ciernik@ Corresponding author Published 18 August 2006 Received II May 2006 Radiation Oncology 2006 1 29 doi 1748-717X-1-29 Accepted 18 August 2006 This article is available from http content 1 1 29 2006 Oehler-Janne et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Purpose To investigate the outcome of HIV-seropositive patients under highly active antiretroviral treatment HAART with anal cancer treated with radiotherapy RT alone or in combination with standard chemotherapy CT . Patients and methods Clinical outcome of 81 HIV-seronegative patients 1988 - 2003 and 10 consecutive HIV-seropositive patients under HAART 1997 - 2003 that were treated with 3-D conformal RT of Gy and standard 5-fluorouracil and mitomycin-C were retrospectively analysed. 10 TNM-stage and age matched HIV-seronegative patients 1992 - 2003 were compared with the 10 HIV-seropositive patients. Pattern of care local disease control LC overall survival OS cancer-specific survival CSS and toxicity were assessed. Results RT with or without CT resulted in complete response in 100 of HIV-seropositive patients. LC was impaired compared .