tailieunhanh - Báo cáo y học: Review Cells of the synovium in rheumatoid arthritis

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Review Cells of the synovium in rheumatoid arthritis. | Available online http content 9 5 220 Review Cells of the synovium in rheumatoid arthritis Chondrocytes Miguel Otero and Mary B Goldring Research Division of the Hospital for Special Surgery Weill College of Medicine of Cornell University Caspary Research Building 535 E. 70th Street New York NY 10021 USA Corresponding author Mary B Goldring goldringm@ Published 26 October 2007 This article is online at http content 9 5 220 2007 BioMed Central Ltd Arthritis Research Therapy 2007 9 220 doi ar2292 Abstract Rheumatoid arthritis RA is one of the inflammatory joint diseases in a heterogeneous group of disorders that share features of destruction of the extracellular matrices of articular cartilage and bone. The underlying disturbance in immune regulation that is responsible for the localized joint pathology results in the release of inflammatory mediators in the synovial fluid and synovium that directly and indirectly influence cartilage homeostasis. Analysis of the breakdown products of the matrix components of joint cartilage in body fluids and quantitative imaging techniques have been used to assess the effects of the inflammatory joint disease on the local remodeling of joint structures. The role of the chondrocyte itself in cartilage destruction in the human rheumatoid joint has been difficult to address but has been inferred from studies in vitro and in animal models. This review covers current knowledge about the specific cellular and biochemical mechanisms that account for the disruption of the integrity of the cartilage matrix in RA. Rheumatoid arthritis Rheumatoid arthritis RA is an inflammatory joint disease that most frequently affects the anatomical components of articular and juxta-articular tissues of diarthrodial joints. The diarthrodial joints join two opposing bone surfaces that are covered by a specialized hyaline cartilage providing a low-friction articulating interface. The synovium lines .