tailieunhanh - Báo cáo y học: "Peroxisome proliferator-activated receptor γ1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1β in articular chondrocytes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Peroxisome proliferator-activated receptor γ1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1β in articular chondrocytes. | Available online http content 9 2 R31 Research article Peroxisome proliferator-activated receptor y1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1 p in articular chondrocytes Hassan Afif1 Mohamed Benderdour2 Leandra Mfuna-Endam1 Johanne Martel-Pelletier1 Jean-Pierre Pelletier1 Nicholas Duval3 and Hassan Fahmi1 Osteoarthritis Research Unit Centre Hospitalier de l Universite de Montreal CHUM Notre-Dame Hospital Department of Medicine University of Montreal Montreal 1560 Sherbrooke East Pavillon DeSève Y-2628 Montreal QC H2L 4M1 Canada 2Centre de Recherche Sacré-Coeur Hospital 5400 Boulevard Gouin Ouest Montreal QC H4J 1C5 Canada 3Centre de Convalescence Pavillon de Charmilles 1 487 Boulevard des Laurentides Montreal QC H7M 2Y3 Canada Corresponding author Hassan Fahmi Received 30 Oct 2006 Revisions requested 11 Jan 2007 Revisions received 26 Feb 2007 Accepted 26 Mar 2007 Published 26 Mar 2007 Arthritis Research Therapy 2007 9 R31 doi ar2151 This article is online at http content 9 2 R31 2007 Afif et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Peroxisome proliferator-activated receptor Y PPARy is a nuclear receptor involved in the regulation of many cellular processes. We and others have previously shown that PPARy activators display anti-inflammatory and chondroprotective properties in vitro and improve the clinical course and histopathological features in an experimental animal model of osteoarthritis OA . However the expression and regulation of PPARy expression in cartilage are poorly defined. This study was undertaken to investigate the quantitative expression and .