tailieunhanh - Báo cáo y học: "A pilot study of IL-1 inhibition by anakinra in acute gout"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: A pilot study of IL-1 inhibition by anakinra in acute gout. | Available online http content 9 2 R28 Research article A pilot study of IL-1 inhibition by anakinra in acute gout Alexander So1 Thibaut De Smedt2 Sylvie Revaz1 and Jurg Tschopp3 Open Access Service of Rhumatologie Department of Medicine Centre Hospitalier Universtaire Vaudois and University of Lausanne 1011 Lausanne Switzerland 2Apoxis SA Avenue de Sévelin 18-20 1004 Lausanne Switzerland institute of Biochemistry University of Lausanne chemin de Boveresses 155 1066 Epalinges Switzerland Corresponding author Alexander So Received 13 Feb 2007 Revisions requested 1 Mar 2007 Revisions received 5 Mar 2007 Accepted 12 Mar 2007 Published 12 Mar 2007 Arthritis Research Therapy 2007 9 R28 doi ar2143 This article is online at http content 9 2 R28 2007 So et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Monosodium urate crystals stimulate monocytes and macrophages to release IL-10 through the NALP3 component of the inflammasome. The effectiveness of IL-1 inhibition in hereditary autoinflammatory syndromes with mutations in the NALP3 protein suggested that IL-1 inhibition might also be effective in relieving the inflammatory manifestations of acute gout. The effectiveness of IL-1 inhibition was first evaluated in a mouse model of monosodium urate crystal-induced inflammation. IL-1 inhibition prevented peritoneal neutrophil accumulation but TNF blockade had no effect. Based on these findings we performed a pilot open-labeled study trial registration number ISRCTN10862635 in 10 patients with gout who could not tolerate or had failed standard antiinflammatory therapies. All patients received 100 mg anakinra daily for 3 days. All 10 patients .

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