tailieunhanh - Báo cáo y học: "Quantitative gait analysis as a method to assess mechanical hyperalgesia modulated by disease-modifying antirheumatoid drugs in the adjuvant-induced arthritic rat"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Quantitative gait analysis as a method to assess mechanical hyperalgesia modulated by disease-modifying antirheumatoid drugs in the adjuvant-induced arthritic rat. | Available online http content 9 5 R91 Open Access Research article Quantitative gait analysis as a method to assess mechanical hyperalgesia modulated by disease-modifying antirheumatoid drugs in the adjuvant-induced arthritic rat Shabana Usman Simjee1 Huma Jawed1 Javeria Quadri2 and Sheikh Arshad Saeed2 1HEJ Research Institute of Chemistry International Centre for Chemical and Biological Sciences University of Karachi Karachi 75270 Pakistan 2Dr Panjwani Centre for Molecular Medicine and Drug Research International Centre for Chemical and Biological Sciences University of Karachi Karachi 75270 Pakistan Corresponding author Shabana Usman Simjee Received 23 May 2007 Revisions requested 1 0 Aug 2007 Revisions received 21 Aug 2007 Accepted 11 Sep 2007 Published 11 Sep 2007 Arthritis Research Therapy 2007 9 R91 doi ar2290 This article is online at http content 9 5 R91 2007 Simjee et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract In the present study azothioprine chloroquine D-penicillamine methotrexate and sodium aurothiomalate gold salt were evaluated for possible disease-modifying effects in the adjuvant-induced arthritis model of human rheumatoid arthritis in rats. Gait analysis was used to examine the role of disease-modifying antirheumatic drugs in the development of pain. Body weights were also measured to monitor the progression of disease and the systemic antiarthritic effects of the test compounds used in this study as well as their systemic toxicity. Our results showed that azothioprine 5 mg kg day chloroquine mg kg day sodium aurothiomalate mg kg day and methotrexate 1 mg kg week not only inhibited the macroscopic .