tailieunhanh - Báo cáo khoa học: " Cisplatin chemotherapy (without erythropoietin) and risk of life-threatening thromboembolic events in carcinoma of the uterine cervix: the tip of the iceberg? A review of the literature"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " Cisplatin chemotherapy (without erythropoietin) and risk of life-threatening thromboembolic events in carcinoma of the uterine cervix: the tip of the iceberg? A review of the literature. | Radiation Oncology BioMed Central Open Access Review Cisplatin chemotherapy without erythropoietin and risk of life-threatening thromboembolic events in carcinoma of the uterine cervix the tip of the iceberg A review of the literature Jon C Anders1 Perry W Grigsby2 and Anurag K Singh 3 Address Radiation Oncology Associates Albuquerque NM 87109 USA 2Washington University School of Medicine Department of Radiation Oncology St. Louis MO 63110 USA and 3National Cancer Institute Radiation Oncology Branch Bethesda MD 20892 USA Email Jon C Anders - andersj11@ Perry W Grigsby-pgrigsby@ Anurag K Singh - singan@ Corresponding author Published 05 May 2006 Received 13 January 2006 Radiation Oncology 2006 1 14 doi 1748-717X-1-14 Accepted 05 May 2006 This article is available from http content l l l4 2006 Anders et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The risk of severe cardiovascular toxicity specifically thromboembolic events TE in patients with cervical cancer receiving concurrent irradiation and cisplatin chemotherapy is reported to be less than 1 in several large prospective trials. However the anecdotal risk appears to be far higher. Results and discussion A review of several prospective trials demonstrates no treatment related grade 4 cardiovascular toxicities and only two grade 5 toxicities in 1424 collective patients. A recent publication and our own unpublished experience finds 6 of 128 patients developed grade 4 to 5 cardiovascular thrombosis embolism toxicity. The differenc in incidence of severe or life threatening cardiovascular toxicity

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